Faculty » Chandra A. Reynolds

My primary research focuses on how and why individuals differ from one another in health and cognition across development. Multiple projects in my lab address the following general questions, with attention to longitudinal models and methods:

I. Why do some individuals show rapid decline in cognitive functioning with age while others remain stable or decline relatively less?
My work in this area has entailed: identifying the most sensitive ways of looking at cognitive change, examining twin similarity and differences in change, considering health and psychosocial correlates of change, and gene-environment interactions. For example, with support from the National Institute on Aging (NIA) we have considered cholesterol, inflammatory, and related gene pathways that may influence cognitive change and decline (AG028555). In addition, I participate in the IGEMS consortium of longitudinal twin studies spanning the US and Scandinavian populations where models of gene-environment interplay for aging outcomes, including cognitive aging, are a feature (AG037985).

II. What early life and life-course factors are important to cognitive maintenance, health and longevity?
Continuing projects examine the influence of early-life, social contexts, and social relationships on later cognition, health, and well-being. I am a co-investigator on the longitudinal Colorado Adoption Project, examining early life factors and contexts that influence cognitive, health and well-being profiles into the early-adulthood period (HD010333). In addition, via the IGEMS consortium, the basis of association among early life adversity and social factors on diverse aging outcomes is a key topic (AG037985). Additional related projects include studies of the interrelationships between physical health and psychosocial trajectories on later life health and longevity in the Terman Life Cycle Study (AG027001).

Selected Publications

Reynolds, C. A., Finkel, D., & Zavala, C. (2014). Gene by Environment Interplay in Cognitive Aging. In D. Finkel & C. A. Reynolds (Eds.), Behavior Genetics of Cognition Across the Lifespan (Vol. 1, pp. 169-199): Springer New York.

Duggan, K. A., Reynolds, C. A., Kern, M. L., & Friedman, H. S. (2014, March 3). Childhood Sleep Duration and Lifelong Mortality Risk.  Health Psychology. Advance online publication. http://dx.doi.org/10.1037/hea0000078

Dahl, A.K., Reynolds, C.A., Fall, T., Magnusson, P.K.E., & Pedersen, N.L. (2014) Multifactorial Analysis of Changes in Body Mass Index across the Adult Life Course – A Study with 65 Years of Follow-up. International Journal of Obesity, 38, 1133-41. 133-41. doi: 10.1038/ijo.2013.204. Epub 2013 Nov 6.

Tucker-Drob, E. M., Reynolds, C. A., Finkel, D., & Pedersen, N. L. (2014). Shared and Unique Genetic and Environmental Influences on Aging-Related Changes in Multiple Cognitive Abilities. Developmental Psychology, 50,152-66. doi: 10.1037/a0032468. Epub 2013 Apr 15.

Reynolds, C. A., Zavala, C., Gatz, M., Vie, L., Johansson, B., Malmberg, B., Ingelsson, E., Prince, J. A., & Pedersen, N. L. (2013). Sortilin receptor 1 predicts longitudinal cognitive change. Neurobiology of Aging. doi: http://dx.doi.org/10.1016/j.neurobiolaging.2012.12.006

Pedersen, N. L., Christensen, K., Dahl, A. K., Finkel, D., Franz, C. E., Gatz, M., Horwitz, B. N., ...., & Reynolds, C. A. (2013). IGEMS: the consortium on Interplay of Genes and Environment across Multiple Studies. Twin Research and Human Genetics, 16, 481-489. doi: 10.1017/thg.2012.110

Davies, G., Harris, S. E., Reynolds, C. A., Payton, A., Knight, H. M., Liewald, D. C., Lopez, L. M., … & Deary, I. J (2014). A genome-wide association study implicates the APOE locus in nonpathological cognitive ageing. Molecular Psychiatry, 19, 76–87; doi:10.1038/mp.2012.159; published online 4 December 2012

Reynolds, C. A., Gatz, M., Pedersen, N. L., & Prince, J. A. (2011). An assessment of CETP sequence variation in relation to cognitive decline and dementia risk. Int J Mol Epidemiol Genet, 2(2), 122-129.

Kern, M.L., Reynolds, C.A., & Friedman, H.S. (2010). Predictors of Physical Activity Patterns Across Adulthood:  A Growth Curve Analysis. Personality and Social Psychology Bulletin, 36,1058-1072.

Reynolds C.A., Gatz, M., Prince, J.A., Berg, S., & Pedersen, N.L. (2010). Serum lipid levels and cognitive change in late life. Journal of the American Geriatrics Society, 58, 501-509.

Reynolds, C.A., Hong, M-G., Eriksson, U., Blennow, K., Wiklund, F., Johansson, B., Malmberg, B., …, & Prince, J.A. (2010). Analysis of lipid pathway genes indicates association of sequence variation near SREBF1/TOM1L2/ATPAF2/ with dementia risk. Human Molecular Genetics, 19, 2068-2078.

Friedman H.S., Kern M.L., & Reynolds C.A. (2010). Personality and Health, Subjective Well-Being, and Longevity. Journal of Personality,78, 179-216.

Reynolds, C.A., Gatz, M., Berg, S., & Pedersen, N.L. (2007). Genotype-Environment Interactions: Cognitive Aging and Social Factors. Twin Research and Human Genetics, 10, 241-254.

Reynolds, C.A., Fiske, A., Fratiglioni, L., Pedersen, N.L., & Gatz, M. (2006). Heritability of an age-dependent categorical phenotype: Cognitive dysfunction. Twin Research and Human Genetics, 9, 17-23.

Reynolds, C.A., Prince, J.A., Feuk, L., Gatz, M., & Pedersen, N.L. (2006). Longitudinal memory performance during normal aging: twin association models of APOE and other Alzheimer candidate genes. Behavior Genetics, 36, 185-94. <Supplemental Appendix Material>

Reynolds, C.A., Barlow, T., & Pedersen, N.L. (2006).  Alcohol, tobacco and caffeine use: Spouse similarity processes. Behavior Genetics, 36, 201-15. <Supplemental Appendix Material>

Reynolds, C.A., Jansson, M., Gatz, M., & Pedersen, N.L. (2006). Longitudinal change in memory performance associated with HTR2A polymorphism. Neurobiology of Aging, 27, 150-4.

Reynolds, C.A., Finkel, D., McArdle, J.J, Gatz, M., Berg, S. & Pedersen, N.L. (2005). Quantitative genetic analysis of latent growth curve models of cognitive abilities in adulthood. Developmental Psychology, 41, 3-16.

Reynolds, C. A., Gatz, M., & Pedersen, N. L. (2002). Individual variation for cognitive decline: Quantitative methods for describing patterns of change. Psychology & Aging, 17, 271-287.

Reynolds, C.A., Baker, L.A., & Pedersen, N.L. (2000). Multivariate models of mixed assortment: phenotypic assortment and social homogamy for education and fluid ability. Behavior Genetics, 30, 455-476.