Faculty » Edward Korzus

My research investigates the functional organization of the prefrontal cortex circuit and its specific role in memory consolidation and psychopathology. Our current study is focused on the role of the prefrontal cortex circuitry in the ability to keep fear memories distinct and resistant to confusion. In this context, we examine the neural mechanisms linked to information encoding, the maturation of synaptic plasticity during the establishment of functional neural circuits, endocannabinoid-dependent synaptic plasticity and the relationships between cortical circuit and behavior.

Using genetic tagging of stimulus-activated neuronal populations in living mice and bidirectional regulation of neural activity via optogenetics, we are currently investigating the circuit-behavior relationships involved in discriminative fear learning. We monitor neural information processing using a genetic model system in conjunction with functional imaging, biochemical, electrophysiological and behavioral techniques.

Selected Publications

Prefrontal NMDA receptors gate discriminatory fear learning.
Vieira, P.A., Corches, A., Lovelace, J.W., Korzus, E. 2014 (Submitted)

Animal model of adolescent cannabis abuse exhibits permanent deficit in presynaptic long-term plasticity.
Lovelace, J.W., Vieira, P.A., Mackie, K., Korzus, E.  2014 (Submitted)

Prefrontal consolidation supports the attainment of fear memory accuracy.
Vieira, P., Lovelace, J.W., Corches, A., Rashid, A.J., Josselyn, S.A., Korzus, E. 2014. Learning & Memory. Vol. 21: 8 p.394-405.

Impaired Fear Memory Specificity Associated with Deficient Endocannabinoid-Dependent Long-Term Plasticity.
Lovelace, J.W., Vieira, P.A., Corches, A., Mackie, K., Korzus, E. 2014. Neuropsychopharmacology. Vol. 39: 28p

Manipulating the brain with epigenetics.
Korzus, E. Nat Neurosci 2010; 13, 405-406.

Impaired maturation of dendritic spines without disorganization of cortical cell layers in mice lacking NRG1/ErbB signaling in the central nervous system.
Barros, C.S., Calabrese, B., Chamero, P., Roberts, A.J., Korzus, E., Lloyd, K., Stowers, L., Mayford, M., Halpain, S. & Muller, U. Proc Natl Acad Sci U S A 2009; 106, 4507-4512.

Epigenetic mechanisms and gene networks in the nervous system.
Colvis, C.M., Pollock, J.D., Goodman, R.H., Impey, S., Dunn, J., Mandel, G., Champagne, F.A., Mayford, M., Korzus, E., Kumar, A., Renthal, W., Theobald, D.E. & Nestler, E.J. J Neurosci 2005; 25, 10379-10389.

Nuclear calcium/calmodulin regulates memory consolidation.
Limback-Stokin, K., Korzus, E., Nagaoka-Yasuda, R. & Mayford, M. J Neurosci 2004; 24, 10858-10867.

CBP histone acetyltransferase activity is a critical component of memory consolidation.
Korzus, E., Rosenfeld, M.G. & Mayford, M. Neuron 2004; 42, 961-972.

Genetics of Memory in the Mouse.
Mayford M., Korzus E. In: Neuropsychology of Memory. Squire L.R. and Schacter D.L. (eds), The Guilford Press, New York. 2002. pp 487-491.

Signal-specific co-activator domain requirements for Pit-1 activation.
Xu, L., Lavinsky, R.M., Dasen, J.S., Flynn, S.E., McInerney, E.M., Mullen, T.M., Heinzel, T., Szeto, D., Korzus, E., Kurokawa, R., Aggarwal, A.K., Rose, D.W., Glass, C.K. & Rosenfeld, M.G. Nature 1998; 395, 301-306.

Transcription factor-specific requirements for coactivators and their acetyltransferase functions.
Korzus, E., Torchia, J., Rose, D.W., Xu, L., Kurokawa, R., McInerney, E.M., Mullen, T.M., Glass, C.K. & Rosenfeld, M.G. Science 1998; 279, 703-707.